5-AMINO-1MQ-10mg

5-Amino-1MQ (5-Amino-1-methylquinolinium) is a potent and selective inhibitor of Nicotinamide N-Methyltransferase (NNMT), an enzyme increasingly recognized as a key regulator of cellular metabolism, energy balance, and age-related physiological processes. Through its targeted inhibition of NNMT activity, 5-Amino-1MQ has emerged as a highly promising research compound in the fields of metabolic health, mitochondrial biology, body composition, and longevity science.

NNMT plays a critical role in the conversion of nicotinamide (NAM) into 1-methylnicotinamide (1-MNA), a process that can influence cellular NAD+ availability and broader metabolic pathways. By inhibiting NNMT, 5-Amino-1MQ has been shown in preclinical research to support increased intracellular NAD+ levels, a key coenzyme involved in mitochondrial energy production, cellular repair mechanisms, and metabolic regulation. This mechanism has generated substantial interest in its potential role as a tool for investigating metabolic efficiency and cellular resilience.

Research has explored the effects of 5-Amino-1MQ on adipose tissue biology, energy expenditure, glucose metabolism, and mitochondrial function. Studies suggest that modulation of NNMT activity may influence pathways associated with fat storage, nutrient utilization, and metabolic flexibility, making the compound a valuable subject of investigation in obesity, insulin resistance, and metabolic syndrome research.

Beyond its metabolic applications, 5-Amino-1MQ has attracted attention within the rapidly growing field of longevity science. Because NAD+ serves as an essential substrate for sirtuins, PARPs, and other enzymes involved in cellular maintenance and genomic stability, NNMT inhibition is being explored as a potential strategy for supporting healthy aging, mitochondrial health, and cellular function over time.

As scientific understanding of metabolic regulation and NAD+ biology continues to evolve, 5-Amino-1MQ remains at the forefront of research examining the intersection of energy metabolism, body composition, mitochondrial performance, and age-related physiological decline. Its highly targeted mechanism of action has established it as a compelling compound for advancing the study of metabolic health and cellular longevity.

CAS Number: 16096-31-4
Molecular Formula: C₁₀H₁₁N₂Cl
Molecular Weight: 194.66 g/mol
Appearance: Orange Powder

Research Use Only
This product is intended solely for in vitro laboratory research purposes. It is not approved for human or animal use and must not be used in food, dietary supplements, pharmaceuticals, or cosmetic applications. All products arrive in lyophilized (freeze-dried) powder form.

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